Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L22L

c.66A>C

Surrounding Variants

6 papers

NM_000546.6

p.L22L

c.66A>T

3 papers

NM_000546.6

p.L22L

c.66A>G

1 paper

NM_000546.6

p.L22_W23insFs

c.66_67ins4

4 papers

NM_000546.6

p.L22fs

c.64_65fs

1 paper

NM_000546.6

p.L22Fs

c.65_66delinsCFs

2 papers

NM_000546.6

p.L22delFs

c.65delA

1 paper

NM_000546.6

p.S20_L22delFs

c.59_65del7

1 paper

NM_000546.6

p.L22insFs

c.65_66ins4

5 papers

NM_000546.6

p.L22insFs

c.66dupA

11 papers

NM_000546.6

p.W23G

c.67T>G

10 papers

NM_000546.6

p.L22R

c.65T>G

10 papers

NM_000546.6

p.L22P

c.65T>C