Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F19_D21delFs

c.57_63del7

Surrounding Variants

5 papers

NM_000546.6

p.L22L

c.64C>T

14 papers

NM_000546.6

p.L22V

c.64C>G

1 paper

NM_000546.6

p.D21_L22ins3

c.63_64ins9

1 paper

NM_000546.6

p.L22_W23insC

c.64_68ins3

10 papers

NM_000546.6

p.L22I

c.64C>A

1 paper

NM_000546.6

p.S20_D21del2

c.58_62del6

1 paper

NM_000546.6

p.T18_D21del0

c.52_63del12

1 paper

NM_000546.6

p.L14_L22delins

c.42_64delinsTCCAA

6 papers

NM_000546.6

p.L22fs

c.64_65fs

1 paper

NM_000546.6

p.L22insFs

c.65_66ins4

10 papers

NM_000546.6

p.L22R

c.65T>G

10 papers

NM_000546.6

p.L22P

c.65T>C