Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.F19S

c.56T>C

Surrounding Variants

1 paper

NM_000546.6

p.T18_F19insFs

c.54_55insAT

1 paper

NM_000546.6

p.F19ins1

c.56_57insGCC

7 papers

NM_000546.6

p.F19C

c.56T>G

7 papers

NM_000546.6

p.F19Y

c.56T>A

1 paper

NM_000546.6

p.T18_F19delFs

c.54_55delAT

2 papers

NM_000546.6

p.T18_F19delins

c.53_56delinsT

1 paper

NM_000546.6

p.E17_F19delFs

c.51_55del5

1 paper

NM_000546.6

p.E17_F19delFs

c.49_55del7

1 paper

NM_000546.6

p.F19_S20insFs

c.57_58insG

1 paper

NM_000546.6

p.F19_S20ins2

c.57_58ins6

2 papers

NM_000546.6

p.T18insFs

c.54dupA

9 papers

NM_000546.6

p.F19L

c.57T>G