Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.Q16H

c.48G>T

Surrounding Variants

1 paper

NM_000546.6

p.Q16_E17ins4

c.48_49ins12

5 papers

NM_000546.6

p.Q16fs

c.46_47fs

1 paper

NM_000546.6

p.Q16insFs

c.47dupA

8 papers

NM_000546.6

p.Q16H

c.48G>C

4 papers

NM_000546.6

p.Q16Q

c.48G>A

1 paper

NM_000546.6

p.Q16delFs

c.47delT

1 paper

NM_000546.6

p.Q16delFs

c.46_47delTG

1 paper

NM_000546.6

p.E17*

c.49G>T

7 papers

NM_000546.6

p.E17Q

c.49G>C

49 papers

NM_000546.6

p.E17K

c.49G>A

4 papers

NM_000546.6

p.S15_Q16delFs

c.43_46del4

1 paper

NM_000546.6

p.L14_Q16del3

c.40_47del9