Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.L14insFs

c.40dupC

Surrounding Variants

1 paper

NM_000546.6

p.L14insFs

c.41_42ins4

6 papers

NM_000546.6

p.L14R

c.41T>G

11 papers

NM_000546.6

p.L14P

c.41T>C

50 papers

NM_000546.6

p.L14Q

c.41T>A

1 paper

NM_000546.6

p.P12_P13delFs

c.36_39del4

1 paper

NM_000546.6

p.P12_P13del2

c.34_38del6

1 paper

NM_000546.6

p.S9_L14Fs

c.25_41delinsGFs

1 paper

NM_000546.6

p.L14L

c.42G>T

1 paper

NM_000546.6

p.L14Fs

c.42delinsATFs

1 paper

NM_000546.6

p.P13insFs

c.38_39insCT

1 paper

NM_000546.6

p.L14insFs

c.41_42ins5

6 papers

NM_000546.6

p.L14fs

c.40_41fs