Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E11insFs

c.31_32insGT

Surrounding Variants

9 papers

NM_000546.6

p.E11V

c.32A>T

7 papers

NM_000546.6

p.E11G

c.32A>G

8 papers

NM_000546.6

p.E11A

c.32A>C

1 paper

NM_000546.6

p.E11insFs

c.32_33ins7

10 papers

NM_000546.6

p.E11D

c.33G>T

5 papers

NM_000546.6

p.E11*

c.31G>T

1 paper

NM_000546.6

p.E11fs

c.31_32fs

105 papers

NM_000546.6

p.E11Q

c.31G>C

10 papers

NM_000546.6

p.E11D

c.33G>C

46 papers

NM_000546.6

p.E11K

c.31G>A

3 papers

NM_000546.6

p.E11E

c.33G>A

1 paper

NM_000546.6

p.E11delins

c.33delinsATCA