Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

37 papers

NM_000546.6

p.V10I

c.28G>A

Surrounding Variants

12 papers

NM_000546.6

p.V10F

c.28G>T

1 paper

NM_000546.6

p.V10insFs

c.28_29insT

1 paper

NM_000546.6

p.S9insFs

c.27dupC

1 paper

NM_000546.6

p.S9_V10insFs

c.27_28ins17

1 paper

NM_000546.6

p.V10insFs

c.28_29insA

17 papers

NM_000546.6

p.V10L

c.28G>C

1 paper

NM_000546.6

p.P8_S9del2

c.22_26del6

1 paper

NM_000546.6

p.M1_S9del9

c.1_26del27

1 paper

NM_000546.6

p.V10insFs

c.29_30insC

2 papers

NM_000546.6

p.V10insFs

c.29_30insA

17 papers

NM_000546.6

p.V10G

c.29T>G

15 papers

NM_000546.6

p.V10A

c.29T>C