Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_000546.6

p.S9R

c.27C>G

Surrounding Variants

6 papers

NM_000546.6

p.S9S

c.27C>T

1 paper

NM_000546.6

p.S9ins1

c.26_27insGGT

1 paper

NM_000546.6

p.S9_V10insFs

c.27_28insGG

1 paper

NM_000546.6

p.S9insFs

c.26_27ins7

11 papers

NM_000546.6

p.S9R

c.27C>A

1 paper

NM_000546.6

p.S9delFs

c.26delC

1 paper

NM_000546.6

p.D7_S9delins

c.21_27delinsC

12 papers

NM_000546.6

p.V10F

c.28G>T

7 papers

NM_000546.6

p.S9I

c.26G>T

1 paper

NM_000546.6

p.S9Fs

c.26delinsATFs

1 paper

NM_000546.6

p.V10insFs

c.28_29insT

1 paper

NM_000546.6

p.S9insFs

c.27dupC