Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.M1del1

c.1_2delCAT

Surrounding Variants

16 papers

NM_000546.6

p.E2*

c.4G>T

2 papers

NM_000546.6

p.M1Fs

c.3delinsGTFs

1 paper

NM_000546.6

p.M1insFs

c.2_3dupTG

1 paper

NM_000546.6

p.E2ins5

c.4_5ins15

1 paper

NM_000546.6

p.M1ins0

c.1_3dupATG

1 paper

NM_000546.6

p.E2insFs

c.4_5insC

1 paper

NM_000546.6

p.E2insFs

c.4_5ins4

1 paper

NM_000546.6

p.E2insFs

c.4_5insCC

19 papers

NM_000546.6

p.E2Q

c.4G>C

22 papers

NM_000546.6

p.E2K

c.4G>A

37 papers

NM_000546.6

p.M1I

c.3G>T

23 papers

NM_000546.6

p.M1insFs

c.2dupT