Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M1_E2ins1

c.3_4insAGA

Surrounding Variants

37 papers

NM_000546.6

p.M1I

c.3G>T

23 papers

NM_000546.6

p.M1insFs

c.2dupT

1 paper

NM_000546.6

p.M1_E2ins1

c.3_4insTCT

1 paper

NM_000546.6

p.M1insFs

c.2_3ins5

1 paper

NM_000546.6

p.M1insFs

c.2_3ins4

1 paper

NM_000546.6

p.M1insFs

c.1_2dupAT

1 paper

NM_000546.6

p.M1_E2insFs

c.3_4ins11

7 papers

NM_000546.6

p.M1fs

c.1_2fs

1 paper

NM_000546.6

p.M1_E2insFs

c.3_4insA

23 papers

NM_000546.6

p.M1I

c.3G>C

41 papers

NM_000546.6

p.M1I

c.3G>A

4 papers

NM_000546.6

p.M1delFs

c.2delA