Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M1delFs

c.1delT

Surrounding Variants

6 papers

NM_000546.6

p.M1insFs

c.2_3insG

1 paper

NM_000546.6

p.M1insFs

c.2_3insC

12 papers

NM_000546.6

p.M1insFs

c.1dupA

1 paper

NM_000546.6

p.M1insFs

c.2_3ins4

16 papers

NM_000546.6

p.M1R

c.2T>G

1 paper

NM_000546.6

p.M1Fs

c.2delinsCTGFs

2 papers

NM_000546.6

p.M1delins

c.2delinsGGGG

24 papers

NM_000546.6

p.M1T

c.2T>C

11 papers

NM_000546.6

p.M1K

c.2T>A

1 paper

NM_000546.6

p.M1delins

c.1delinsA

37 papers

NM_000546.6

p.M1I

c.3G>T

23 papers

NM_000546.6

p.M1insFs

c.2dupT