Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

28 papers

NM_000546.6

p.M1V

c.1A>G

Surrounding Variants

20 papers

NM_000546.6

p.M1L

c.1A>T

2 papers

NM_000546.6

p.M1Fs

c.1delinsCTFs

18 papers

NM_000546.6

p.M1L

c.1A>C

1 paper

NM_000546.6

p.M1Fs

c.1delinsTCFs

2 papers

NM_000546.6

p.M1insFs

c.1_2insT

1 paper

NM_000546.6

p.M1insFs

c.1_2insG

1 paper

NM_000546.6

p.M1insFs

c.1_2insC

1 paper

NM_000546.6

p.M1_E2insT

c.1_5ins3

6 papers

NM_000546.6

p.M1insFs

c.2_3insG

1 paper

NM_000546.6

p.M1insFs

c.2_3insC

12 papers

NM_000546.6

p.M1insFs

c.1dupA

1 paper

NM_000546.6

p.M1insFs

c.2_3ins4