Varaico: Literature-Extracted Genetic Variants

TPP2

89 papers

RefSeq Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I a...

Pfam Domains

Peptidase_S8aa 35–500UCSCSubtilase family

TPPII_Ig-like-1aa 521–634UCSCTripeptidyl-peptidase II, first Ig-like domain

TPPII_GBDaa 654–742UCSCTPPII, galactose-binding domain-like

TPPIIaa 777–964UCSCTripeptidyl peptidase II

TPPII_Caa 1018–1086UCSCTripeptidyl peptidase II, C-terminal

Gene Aliases

HGNC Name

tripeptidyl peptidase 2

HGNC Alias Symbol

TPPII

Papers

RefSeq ID

Protein change

DNA change

1–12 of 90 variants

3 papers

NM_001330588.2

p.C28G

c.82T>G

3 papers

NM_001330588.2

p.V144delFs

c.432delG

3 papers

NM_001330588.2

p.G252R

c.754G>A

3 papers

NM_001330588.2

p.G252R

c.754G>C

3 papers

NM_001330588.2

p.G500D

c.1499G>A

3 papers

NM_001330588.2

p.Y781*

c.2343C>G

2 papers

NM_001330588.2

p.A41T

c.121G>A

2 papers

NM_001330588.2

p.N77H

c.229A>C

2 papers

NM_001330588.2

p.A145fs

c.433_434fs

2 papers

NM_001330588.2

p.V246I

c.736G>A

2 papers

NM_001330588.2

p.E331Q

c.991G>C

2 papers

NM_001330588.2

p.S449A

c.1345T>G