Varaico: Literature-Extracted Genetic Variants

TPP2

89 papers

RefSeq Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I a...

Pfam Domains

Peptidase_S8aa 35–500UCSCSubtilase family

TPPII_Ig-like-1aa 521–634UCSCTripeptidyl-peptidase II, first Ig-like domain

TPPII_GBDaa 654–742UCSCTPPII, galactose-binding domain-like

TPPIIaa 777–964UCSCTripeptidyl peptidase II

TPPII_Caa 1018–1086UCSCTripeptidyl peptidase II, C-terminal

Gene Aliases

HGNC Name

tripeptidyl peptidase 2

HGNC Alias Symbol

TPPII

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330588.2

p.D75Y

c.223G>T

Surrounding Variants

1 paper

NM_001330588.2

p.V76M

c.226G>A

2 papers

NM_001330588.2

p.N77H

c.229A>C

1 paper

NM_001330588.2

p.D66V

c.197A>T

1 paper

NM_001330588.2

p.T57delFs

c.171delA

1 paper

NM_001330588.2

p.T57A

c.169A>G

2 papers

NM_001330588.2

p.A41T

c.121G>A

3 papers

NM_001330588.2

p.C28G

c.82T>G

1 paper

NM_001330588.2

p.C28fs

c.82_83fs

1 paper

NM_001330588.2

p.C28delFs

c.83delG

1 paper

NM_001330588.2

p.T21T

c.63C>A

1 paper

NM_001330588.2

p.E20E

c.60G>A

1 paper

NM_001330588.2

p.K19K

c.57G>A