Varaico: Literature-Extracted Genetic Variants

TPP2

89 papers

RefSeq Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I a...

Pfam Domains

Peptidase_S8aa 35–500UCSCSubtilase family

TPPII_Ig-like-1aa 521–634UCSCTripeptidyl-peptidase II, first Ig-like domain

TPPII_GBDaa 654–742UCSCTPPII, galactose-binding domain-like

TPPIIaa 777–964UCSCTripeptidyl peptidase II

TPPII_Caa 1018–1086UCSCTripeptidyl peptidase II, C-terminal

Gene Aliases

HGNC Name

tripeptidyl peptidase 2

HGNC Alias Symbol

TPPII

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_001330588.2

p.A145fs

c.433_434fs

Surrounding Variants

3 papers

NM_001330588.2

p.V144delFs

c.432delG

1 paper

NM_001330588.2

p.A147P

c.439G>C

1 paper

NM_001330588.2

p.N160S

c.479A>G

1 paper

NM_001330588.2

p.N161N

c.483C>T

1 paper

NM_001330588.2

p.I114V

c.340A>G

1 paper

NM_001330588.2

p.G113D

c.338G>A

1 paper

NM_001330588.2

p.Q177P

c.530A>C

1 paper

NM_001330588.2

p.D196E

c.588C>A

1 paper

NM_001330588.2

p.D196E

c.588C>G

1 paper

NM_001330588.2

p.R207Splc

c.621-1G>C

1 paper

NM_001330588.2

p.K220*

c.658A>T

1 paper

NM_001330588.2

p.R225G

c.673A>G