Varaico: Literature-Extracted Genetic Variants

TPP2

89 papers

RefSeq Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I a...

Pfam Domains

Peptidase_S8aa 35–500UCSCSubtilase family

TPPII_Ig-like-1aa 521–634UCSCTripeptidyl-peptidase II, first Ig-like domain

TPPII_GBDaa 654–742UCSCTPPII, galactose-binding domain-like

TPPIIaa 777–964UCSCTripeptidyl peptidase II

TPPII_Caa 1018–1086UCSCTripeptidyl peptidase II, C-terminal

Gene Aliases

HGNC Name

tripeptidyl peptidase 2

HGNC Alias Symbol

TPPII

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001330588.2

p.K864R

c.2591A>G

Surrounding Variants

1 paper

NM_001330588.2

p.D861Y

c.2581G>T

1 paper

NM_001330588.2

p.I859T

c.2576T>C

1 paper

NM_001330588.2

p.P831S

c.2491C>T

1 paper

NM_001330588.2

p.S801N

c.2402G>A

1 paper

NM_001330588.2

p.P799fs

c.2395_2396fs

1 paper

NM_001330588.2

p.R889*

c.2665C>T

1 paper

NM_001330588.2

p.N938S

c.2813A>G

1 paper

NM_001330588.2

p.V794I

c.2380G>A

2 papers

NM_001330588.2

p.Y781*

c.2343C>A

3 papers

NM_001330588.2

p.Y781*

c.2343C>G

1 paper

NM_001330588.2

p.Q776H

c.2328G>C

1 paper

NM_001330588.2

p.Q776H

c.2328G>T