tetraspanin 8

TM4SF3

CO-029

transmembrane 4 superfamily member 3

Tetraspanin-8

Transmembrane 4 superfamily member 3

Tumor-associated antigen CO-029

Tspan-8

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

TSPAN8

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol