Varaico: Literature-Extracted Genetic Variants

TXNRD2

209 papers

RefSeq Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are fo...

Pfam Domains

Pyr_redox_2aa 40–375UCSCPyridine nucleotide-disulphide oxidoreductase

Pyr_redox_dimaa 395–508UCSCPyridine nucleotide-disulphide oxidoreductase, dimerisation domain

Gene Aliases

HGNC Name

thioredoxin reductase 2

HGNC Alias Symbols

TR; TRXR2; TR3; SELZ; TXNR2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006440.5

p.C446R

c.1336T>C

Surrounding Variants

1 paper

NM_006440.5

p.C446S

c.1336T>A

1 paper

NM_006440.5

p.C446S

c.1337G>C

2 papers

NM_006440.5

p.C446*

c.1338T>A

18 papers

NM_006440.5

p.Y447*

c.1341T>G

16 papers

NM_006440.5

p.Y447*

c.1341T>A

2 papers

NM_006440.5

p.R441Q

c.1322G>A

2 papers

NM_006440.5

p.R441*

c.1321C>T

1 paper

NM_006440.5

p.E435D

c.1305G>C

1 paper

NM_006440.5

p.H430P

c.1289A>C

1 paper

NM_006440.5

p.A429A

c.1287C>A

1 paper

NM_006440.5

p.K449_M450Splc

c.1348-1G>T

1 paper

NM_006440.5

p.M450fs

c.1348_1349fs