Varaico: Literature-Extracted Genetic Variants

Gene:TYMS
Variant:p.L118V

TYMS

448 papers

RefSeq Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-pr...

Pfam Domains

Thymidylat_syntaa 31–313UCSCThymidylate synthase

Gene Aliases

HGNC Name

thymidylate synthetase

HGNC Previous Symbol

TS

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001071.4
p.L118V
c.352T>G
Surrounding Variants
2 papers
NM_001071.4
p.F117L
c.351T>A
2 papers
NM_001071.4
p.F117L
c.351T>G
2 papers
NM_001071.4
p.L118F
c.354G>T
3 papers
NM_001071.4
p.F117L
c.349T>C
3 papers
NM_001071.4
p.D116A
c.347A>C
1 paper
NM_001071.4
p.S120N
c.359G>A
1 paper
NM_001071.4
p.S120R
c.360C>G
1 paper
NM_001071.4
p.R115Q
c.344G>A
2 papers
NM_001071.4
p.R115*
c.343C>T
1 paper
NM_001071.4
p.L121L
c.361C>T
4 papers
NM_001071.4
p.S114F
c.341C>T
1 paper
NM_001071.4
p.L121L
c.363G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."