Varaico: Literature-Extracted Genetic Variants

Gene:TYMS
Variant:p.Y146F

TYMS

448 papers

RefSeq Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-pr...

Pfam Domains

Thymidylat_syntaa 31–313UCSCThymidylate synthase

Gene Aliases

HGNC Name

thymidylate synthetase

HGNC Previous Symbol

TS

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001071.4
p.Y146F
c.437A>T
Surrounding Variants
1 paper
NM_001071.4
p.Y146S
c.437A>C
2 papers
NM_001071.4
p.Y146C
c.437A>G
1 paper
NM_001071.4
p.Y146N
c.436T>A
1 paper
NM_001071.4
p.Y146H
c.436T>C
1 paper
NM_001071.4
p.Y146D
c.436T>G
2 papers
NM_001071.4
p.A144S
c.430G>T
1 paper
NM_001071.4
p.M149_S151del0
c.447_452del6
1 paper
NM_001071.4
p.G143R
c.427G>A
1 paper
NM_001071.4
p.G143R
c.427G>C
1 paper
NM_001071.4
p.E150Fs
c.449delinsTTAAAGFs
2 papers
NM_001071.4
p.F142S
c.425T>C
2 papers
NM_001071.4
p.E150D
c.450A>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."