Varaico: Literature-Extracted Genetic Variants

Gene:TYMS
Variant:p.D166H

TYMS

448 papers

RefSeq Summary

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-pr...

Pfam Domains

Thymidylat_syntaa 31–313UCSCThymidylate synthase

Gene Aliases

HGNC Name

thymidylate synthetase

HGNC Previous Symbol

TS

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001071.4
p.D166H
c.496G>C
Surrounding Variants
1 paper
NM_001071.4
p.I165V
c.493A>G
3 papers
NM_001071.4
p.T167I
c.500C>T
9 papers
NM_001071.4
p.R163K
c.488G>A
1 paper
NM_001071.4
p.R163T
c.488G>C
2 papers
NM_001071.4
p.T170S
c.508A>T
2 papers
NM_001071.4
p.Q162_R163delFs
c.486_487delAA
2 papers
NM_001071.4
p.T170S
c.509C>G
1 paper
NM_001071.4
p.L161L
c.481C>T
2 papers
NM_001071.4
p.Q160H
c.480A>C
3 papers
NM_001071.4
p.N171S
c.512A>G
2 papers
NM_001071.4
p.Q160H
c.480A>T
3 papers
NM_001071.4
p.P172S
c.514C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."