Varaico: Literature-Extracted Genetic Variants

TYW2

25 papers

RefSeq Summary

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT1...

Pfam Domains

TYW2_Naa 22–98UCSCTYW2 N-terminal domain

TYW2_N_2aa 119–197UCSCTYW2 N-terminal domain

TRM5-TYW2_MTfaseaa 199–358UCSCTRM5/TYW2 methyltransferase domain

Gene Aliases

HGNC Name

tRNA wybutosine-synthesizing protein 2

HGNC Previous Symbol

TRMT12

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_017956.4

p.D293A

c.878A>C

Surrounding Variants

1 paper

NM_017956.4

p.I302V

c.904A>G

1 paper

NM_017956.4

p.E265A

c.794A>C

4 papers

NM_017956.4

p.G257R

c.769G>C

1 paper

NM_017956.4

p.E358Q

c.1072G>C

1 paper

NM_017956.4

p.S379C

c.1136C>G

1 paper

NM_017956.4

p.G381delFs

c.1143delA

1 paper

NM_017956.4

p.M383fs

c.1147_1148fs

1 paper

NM_017956.4

p.K389R

c.1166A>G

1 paper

NM_017956.4

p.L160V

c.478C>G

1 paper

NM_017956.4

p.R113S

c.337C>A

1 paper

NM_017956.4

p.L89L

c.267C>G

1 paper

NM_017956.4

p.P60L

c.179C>T