ubiquitin conjugating enzyme E2 D1

UbcH5A

UBCH5

UBC4/5

E2(17)KB1

stimulator of Fe transport

ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)

ubiquitin-conjugating enzyme E2D 1

Ubiquitin-conjugating enzyme E2 D1

(E3-independent) E2 ubiquitin-conjugating enzyme D1

E2 ubiquitin-conjugating enzyme D1

Stimulator of Fe transport

UBC4/5 homolog

UbcH5

Ubiquitin carrier protein D1

Ubiquitin-conjugating enzyme E2(17)KB 1

Ubiquitin-conjugating enzyme E2-17 kDa 1

Ubiquitin-protein ligase D1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

Varaico: Literature-Extracted Genetic Variants

UBE2D1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols