ubiquitin conjugating enzyme E2 D2

UbcH5B

UBC4

ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

ubiquitin-conjugating enzyme E2D 2

Ubiquitin-conjugating enzyme E2 D2

(E3-independent) E2 ubiquitin-conjugating enzyme D2

E2 ubiquitin-conjugating enzyme D2

Ubiquitin carrier protein D2

Ubiquitin-conjugating enzyme E2(17)KB 2

Ubiquitin-conjugating enzyme E2-17 kDa 2

Ubiquitin-protein ligase D2

p53-regulated ubiquitin-conjugating enzyme 1

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].

Varaico: Literature-Extracted Genetic Variants

UBE2D2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols