Varaico: Literature-Extracted Genetic Variants

Gene:UBN1
Variant:p.L623F

UBN1

78 papers

RefSeq Summary

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress prol...

Pfam Domains

HUNaa 117–168UCSCHPC2 and ubinuclein domain
UBN_ABaa 353–573UCSCUbinuclein conserved middle domain

Gene Aliases

HGNC Name

ubinuclein 1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001079514.3
p.L623F
c.1869G>T
Surrounding Variants
1 paper
NM_001079514.3
p.L623F
c.1869G>C
1 paper
NM_001079514.3
p.S625A
c.1873T>G
1 paper
NM_001079514.3
p.S633N
c.1898G>A
1 paper
NM_001079514.3
p.L641L
c.1923C>T
1 paper
NM_001079514.3
p.D659Y
c.1975G>T
1 paper
NM_001079514.3
p.R667C
c.1999C>T
1 paper
NM_001079514.3
p.P698_K700del3
c.2092_2099del9
1 paper
NM_001079514.3
p.T712A
c.2134A>G
1 paper
NM_001079514.3
p.S734L
c.2201C>T
1 paper
NM_001079514.3
p.A745S
c.2233G>T
1 paper
NM_001079514.3
p.S749F
c.2246C>T
1 paper
NM_001079514.3
p.E752D
c.2256G>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."