unc-13 homolog B

UNC13

hmunc13

Unc13h2

Munc13-2

unc-13-like (C. elegans)

unc-13 homolog B (C. elegans)

Protein unc-13 homolog B

munc13

Phorbol esters/diacylglycerol binding domain (C1 domain)

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

UNC13B

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol