Varaico: Literature-Extracted Genetic Variants

Gene:USP4
Variant:p.R559W

USP4

92 papers

RefSeq Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in mainta...

Pfam Domains

DUSPaa 31–123UCSCDUSP domain
Ubiquitin_3aa 139–226UCSCUbiquitin-like domain
UCHaa 302–920UCSCUbiquitin carboxyl-terminal hydrolase

Gene Aliases

HGNC Name

ubiquitin specific peptidase 4

HGNC Previous Symbol

UNP

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003363.4
p.R559W
c.1675C>T
Surrounding Variants
1 paper
NM_003363.4
p.R559Q
c.1676G>A
1 paper
NM_003363.4
p.P558H
c.1673C>A
1 paper
NM_003363.4
p.M557I
c.1671G>T
1 paper
NM_003363.4
p.M557I
c.1671G>C
1 paper
NM_003363.4
p.M557I
c.1671G>A
1 paper
NM_003363.4
p.I546V
c.1636A>G
1 paper
NM_003363.4
p.V538L
c.1612G>T
1 paper
NM_003363.4
p.V538L
c.1612G>C
1 paper
NM_003363.4
p.D517N
c.1549G>A
1 paper
NM_003363.4
p.V515M
c.1543G>A
1 paper
NM_003363.4
p.R501T
c.1502G>C
1 paper
NM_003363.4
p.P480S
c.1438C>T
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