Varaico: Literature-Extracted Genetic Variants

Gene:USP4
Variant:p.F386S

USP4

92 papers

RefSeq Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in mainta...

Pfam Domains

DUSPaa 31–123UCSCDUSP domain
Ubiquitin_3aa 139–226UCSCUbiquitin-like domain
UCHaa 302–920UCSCUbiquitin carboxyl-terminal hydrolase

Gene Aliases

HGNC Name

ubiquitin specific peptidase 4

HGNC Previous Symbol

UNP

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003363.4
p.F386S
c.1157T>C
Surrounding Variants
1 paper
NM_003363.4
p.P384S
c.1150C>T
1 paper
NM_003363.4
p.R411Q
c.1232G>A
1 paper
NM_003363.4
p.N424S
c.1271A>G
1 paper
NM_003363.4
p.R426W
c.1276C>T
1 paper
NM_003363.4
p.D428Y
c.1282G>T
1 paper
NM_003363.4
p.K433Q
c.1297A>C
2 papers
NM_003363.4
p.S445A
c.1333T>G
1 paper
NM_003363.4
p.L459V
c.1375T>G
2 papers
NM_003363.4
p.E463K
c.1387G>A
1 paper
NM_003363.4
p.S468F
c.1403C>T
1 paper
NM_003363.4
p.P480S
c.1438C>T
1 paper
NM_003363.4
p.R501T
c.1502G>C
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