Varaico: Literature-Extracted Genetic Variants

VAV2

83 papers

RefSeq Summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tis...

Pfam Domains

CHaa 1–121UCSCCalponin homology (CH) domain

RhoGEFaa 202–374UCSCRhoGEF domain

SOS1_NGEF_PHaa 400–510UCSCSOS1/NGEF-like PH domain

C1_1aa 524–574UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

SH3_2aa 590–650UCSCVariant SH3 domain

Gene Aliases

HGNC Name

vav guanine nucleotide exchange factor 2

HGNC Previous Names

vav 2 oncogene; vav 2 guanine nucleotide exchange factor

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_001134398.2

p.M594V

c.1780A>G

Surrounding Variants

1 paper

NM_001134398.2

p.Y597N

c.1789T>A

1 paper

NM_001134398.2

p.H598R

c.1793A>G

1 paper

NM_001134398.2

p.P589L

c.1766C>T

1 paper

NM_001134398.2

p.G599D

c.1796G>A

1 paper

NM_001134398.2

p.G605W

c.1813G>T

1 paper

NM_001134398.2

p.G605R

c.1813G>C

1 paper

NM_001134398.2

p.G605R

c.1813G>A

1 paper

NM_001134398.2

p.G584R

c.1750G>C

1 paper

NM_001134398.2

p.G584R

c.1750G>A

1 paper

NM_001134398.2

p.P651L

c.1952C>T

1 paper

NM_001134398.2

p.L580_D581Splc

c.1740+48T>C

1 paper

NM_001134398.2

p.P661L

c.1982C>T