VPS37A subunit of ESCRT-I

PQBP2

FLJ32642

HCRP1

SPG53

vacuolar protein sorting 37A (yeast)

polyglutamine binding protein 2

vacuolar protein sorting 37 homolog A (S. cerevisiae)

hepatocellular carcinoma related protein 1

Vacuolar protein sorting-associated protein 37A

ESCRT-I complex subunit VPS37A

Hepatocellular carcinoma-related protein 1

hVps37A

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].

Varaico: Literature-Extracted Genetic Variants

VPS37A

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol