Varaico: Literature-Extracted Genetic Variants

Gene:WEE1
Variant:p.L274I

WEE1

147 papers

RefSeq Summary

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kina...

Pfam Domains

Pkinaseaa 299–569UCSCProtein kinase domain

Gene Aliases

HGNC Name

WEE1 G2 checkpoint kinase

HGNC Alias Symbol

WEE1A

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003390.4
p.L274I
c.820C>A
Surrounding Variants
1 paper
NM_003390.4
p.E277fs
c.829_830fs
1 paper
NM_003390.4
p.E277*
c.829G>T
1 paper
NM_003390.4
p.P280T
c.838C>A
1 paper
NM_003390.4
p.M267fs
c.799_800fs
1 paper
NM_003390.4
p.A281insFs
c.841_842insA
1 paper
NM_003390.4
p.A281fs
c.841_842fs
1 paper
NM_003390.4
p.K282R
c.845A>G
1 paper
NM_003390.4
p.D261Splc
c.782+1G>A
1 paper
NM_003390.4
p.R253H
c.758G>A
1 paper
NM_003390.4
p.I235F
c.703A>T
1 paper
NM_003390.4
p.E298Q
c.892G>C
1 paper
NM_003390.4
p.R228*
c.682C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."