Varaico: Literature-Extracted Genetic Variants

Gene:WEE1
Variant:p.N455H

WEE1

147 papers

RefSeq Summary

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kina...

Pfam Domains

Pkinaseaa 299–569UCSCProtein kinase domain

Gene Aliases

HGNC Name

WEE1 G2 checkpoint kinase

HGNC Alias Symbol

WEE1A

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_003390.4
p.N455H
c.1363A>C
Surrounding Variants
1 paper
NM_003390.4
p.M458L
c.1372A>C
1 paper
NM_003390.4
p.M458L
c.1372A>T
1 paper
NM_003390.4
p.F459Y
c.1376T>A
1 paper
NM_003390.4
p.D450A
c.1349A>C
1 paper
NM_003390.4
p.K460R
c.1379A>G
1 paper
NM_003390.4
p.G462C
c.1384G>T
1 paper
NM_003390.4
p.R436Q
c.1307G>A
1 paper
NM_003390.4
p.E476K
c.1426G>A
1 paper
NM_003390.4
p.E486D
c.1458A>C
1 paper
NM_003390.4
p.E486D
c.1458A>T
1 paper
NM_003390.4
p.E490A
c.1469A>C
1 paper
NM_003390.4
p.E490_N491Splc
c.1471-2A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."