WAP four-disulfide core domain 10B

WAP12

Protein WFDC10B

This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Two alternatively spliced transcript variants have been found for this gene, and they encode distinct isoforms. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

WFDC10B

RefSeq Summary

Gene Aliases

HGNC Name

HGNC Alias Symbol