Varaico: Literature-Extracted Genetic Variants

WNK1

951 papers

RefSeq Summary

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride io...

Pfam Domains

Pkinaseaa 221–479UCSCProtein kinase domain

OSR1_Caa 500–563UCSCOxidative-stress-responsive kinase 1 C-terminal domain

CCTL2_WNKaa 870–947UCSCWNK CCTL2 domain

CCTL2_WNKaa 1117–1194UCSCWNK CCTL2 domain

Gene Aliases

HGNC Name

WNK lysine deficient protein kinase 1

HGNC Previous Symbols

PRKWNK1; HSN2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_018979.4

p.S661F

c.1982C>T

Surrounding Variants

1 paper

NM_018979.4

p.G660G

c.1980A>G

1 paper

NM_018979.4

p.S662_V663insG

c.1984_1988ins3

1 paper

NM_018979.4

p.G660V

c.1979G>T

2 papers

NM_018979.4

p.F664I

c.1990T>A

8 papers

NM_018979.4

p.T665I

c.1994C>T

1 paper

NM_018979.4

p.D652insFs

c.1955_1956ins47

1 paper

NM_018979.4

p.S651_D652insFs

c.1953_1954insA

1 paper

NM_018979.4

p.T674A

c.2020A>G

1 paper

NM_018979.4

p.V690G

c.2069T>G

1 paper

NM_018979.4

p.H693Y

c.2077C>T

3 papers

NM_018979.4

p.A700_Q701delFs

c.2099_2102del4

1 paper

NM_018979.4

p.S702F

c.2105C>T