Varaico: Literature-Extracted Genetic Variants

WNK2

176 papers

RefSeq Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostas...

Pfam Domains

Pkinaseaa 195–453UCSCProtein kinase domain

OSR1_Caa 474–537UCSCOxidative-stress-responsive kinase 1 C-terminal domain

CCTL2_WNKaa 1186–1263UCSCWNK CCTL2 domain

Gene Aliases

HGNC Name

WNK lysine deficient protein kinase 2

HGNC Previous Symbols

SDCCAG43; PRKWNK2

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006648.4

p.G585E

c.1754G>A

Surrounding Variants

1 paper

NM_006648.4

p.G585R

c.1753G>A

1 paper

NM_006648.4

p.G585R

c.1753G>C

1 paper

NM_006648.4

p.P592P

c.1776G>A

1 paper

NM_006648.4

p.P568L

c.1703C>T

1 paper

NM_006648.4

p.T602T

c.1806G>A

1 paper

NM_006648.4

p.P567L

c.1700C>T

1 paper

NM_006648.4

p.S612L

c.1835C>T

1 paper

NM_006648.4

p.V558L

c.1672G>T

1 paper

NM_006648.4

p.A549S

c.1645G>T

1 paper

NM_006648.4

p.W541R

c.1621T>A

1 paper

NM_006648.4

p.W541R

c.1621T>C

1 paper

NM_006648.4

p.K530T

c.1589A>C