WW domain containing E3 ubiquitin protein ligase 2

AIP2

atrophin-1-interacting protein 2

NEDD4-like E3 ubiquitin-protein ligase WWP2

Atrophin-1-interacting protein 2

HECT-type E3 ubiquitin transferase WWP2

WW domain-containing protein 2

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012].

Varaico: Literature-Extracted Genetic Variants

WWP2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol