Varaico: Literature-Extracted Genetic Variants

XRN1

138 papers

RefSeq Summary

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-deca...

Pfam Domains

XRN_Naa 1–227UCSCXRN 5'-3' exonuclease N-terminus

XRN_Maa 272–609UCSCXrn1 helical domain

XRN1_D1aa 646–845UCSCExoribonuclease Xrn1 D1 domain

XRN1_D2_D3aa 848–1081UCSCExoribonuclease Xrn1 D2/D3 domain

SH3_12aa 1101–1171UCSCXrn1 SH3-like domain

Gene Aliases

HGNC Name

5'-3' exoribonuclease 1

HGNC Alias Symbol

SEP1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001282857.2

p.D63N

c.187G>A

Surrounding Variants

3 papers

NM_001282857.2

p.I60T

c.179T>C

1 paper

NM_001282857.2

p.E69A

c.206A>C

1 paper

NM_001282857.2

p.D86G

c.257A>G

1 paper

NM_001282857.2

p.G87A

c.260G>C

1 paper

NM_001282857.2

p.G87D

c.260G>A

1 paper

NM_001282857.2

p.V88V

c.264G>A

1 paper

NM_001282857.2

p.M36T

c.107T>C

1 paper

NM_001282857.2

p.P90L

c.269C>T

1 paper

NM_001282857.2

p.D35A

c.104A>C

1 paper

NM_001282857.2

p.L32F

c.96G>T

1 paper

NM_001282857.2

p.L32F

c.96G>C

1 paper

NM_001282857.2

p.F29L

c.87T>G