Varaico: Literature-Extracted Genetic Variants

Gene:XRN2
Variant:p.E127fs

XRN2

73 papers

RefSeq Summary

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isofo...

Pfam Domains

XRN_Naa 1–254UCSCXRN 5'-3' exonuclease N-terminus
XRN_Maa 325–786UCSCXrn1 helical domain

Gene Aliases

HGNC Name

5'-3' exoribonuclease 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_012255.5
p.E127fs
c.379_380fs
Surrounding Variants
1 paper
NM_012255.5
p.M126delFs
c.378delG
1 paper
NM_012255.5
p.Q133L
c.398A>T
1 paper
NM_012255.5
p.R115H
c.344G>A
1 paper
NM_012255.5
p.L140F
c.420G>C
1 paper
NM_012255.5
p.L140F
c.420G>T
1 paper
NM_012255.5
p.P148L
c.443C>T
1 paper
NM_012255.5
p.A171A
c.513T>A
1 paper
NM_012255.5
p.L98del1
c.292_293delCTC
1 paper
NM_012255.5
p.A80S
c.238G>T
1 paper
NM_012255.5
p.M77fs
c.229_230fs
1 paper
NM_012255.5
p.M77delFs
c.230_231delTG
1 paper
NM_012255.5
p.K72Q
c.214A>C
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."