Varaico: Literature-Extracted Genetic Variants

ZAP70

424 papers

RefSeq Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine resid...

Pfam Domains

SH2aa 10–87UCSCSH2 domain

SH2aa 163–239UCSCSH2 domain

PK_Tyr_Ser-Thraa 338–593UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

zeta chain of T cell receptor associated protein kinase 70

HGNC Previous Symbol

SRK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001079.4

p.P9S

c.25C>T

Surrounding Variants

1 paper

NM_001079.4

p.H7R

c.20A>G

1 paper

NM_001079.4

p.H7Y

c.19C>T

2 papers

NM_001079.4

p.F11L

c.31T>C

1 paper

NM_001079.4

p.A6A

c.18G>A

1 paper

NM_001079.4

p.F11S

c.32T>C

2 papers

NM_001079.4

p.F11L

c.33C>A

1 paper

NM_001079.4

p.F11L

c.33C>G

1 paper

NM_001079.4

p.A6V

c.17C>T

1 paper

NM_001079.4

p.Y12H

c.34T>C

1 paper

NM_001079.4

p.Y12F

c.35A>T

2 papers

NM_001079.4

p.G13S

c.37G>A

2 papers

NM_001079.4

p.G13R

c.37G>C