Varaico: Literature-Extracted Genetic Variants

ZAP70

424 papers

RefSeq Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine resid...

Pfam Domains

SH2aa 10–87UCSCSH2 domain

SH2aa 163–239UCSCSH2 domain

PK_Tyr_Ser-Thraa 338–593UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

zeta chain of T cell receptor associated protein kinase 70

HGNC Previous Symbol

SRK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001079.4

p.A18G

c.53C>G

Surrounding Variants

1 paper

NM_001079.4

p.A18D

c.53C>A

1 paper

NM_001079.4

p.A20G

c.59C>G

1 paper

NM_001079.4

p.S16L

c.47C>T

1 paper

NM_001079.4

p.I15T

c.44T>C

1 paper

NM_001079.4

p.I15V

c.43A>G

1 paper

NM_001079.4

p.S14N

c.41G>A

1 paper

NM_001079.4

p.G13D

c.38G>A

2 papers

NM_001079.4

p.G13S

c.37G>A

2 papers

NM_001079.4

p.G13R

c.37G>C

1 paper

NM_001079.4

p.Y12F

c.35A>T

1 paper

NM_001079.4

p.Y12H

c.34T>C

2 papers

NM_001079.4

p.F11L

c.33C>A