Varaico: Literature-Extracted Genetic Variants

ZAP70

424 papers

RefSeq Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine resid...

Pfam Domains

SH2aa 10–87UCSCSH2 domain

SH2aa 163–239UCSCSH2 domain

PK_Tyr_Ser-Thraa 338–593UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

zeta chain of T cell receptor associated protein kinase 70

HGNC Previous Symbol

SRK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001079.4

p.A70T

c.208G>A

Surrounding Variants

1 paper

NM_001079.4

p.Y69H

c.205T>C

1 paper

NM_001079.4

p.A72G

c.215C>G

1 paper

NM_001079.4

p.G67A

c.200G>C

2 papers

NM_001079.4

p.G67V

c.200G>T

2 papers

NM_001079.4

p.G67S

c.199G>A

1 paper

NM_001079.4

p.G73S

c.217G>A

1 paper

NM_001079.4

p.L65P

c.194T>C

1 paper

NM_001079.4

p.Q64L

c.191A>T

2 papers

NM_001079.4

p.A76T

c.226G>A

1 paper

NM_001079.4

p.A76V

c.227C>T

1 paper

NM_001079.4

p.R63C

c.187C>T

1 paper

NM_001079.4

p.H77R

c.230A>G