Varaico: Literature-Extracted Genetic Variants

ZAP70

424 papers

RefSeq Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine resid...

Pfam Domains

SH2aa 10–87UCSCSH2 domain

SH2aa 163–239UCSCSH2 domain

PK_Tyr_Ser-Thraa 338–593UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

zeta chain of T cell receptor associated protein kinase 70

HGNC Previous Symbol

SRK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001079.4

p.S88A

c.262T>G

Surrounding Variants

2 papers

NM_001079.4

p.Y87*

c.261C>A

3 papers

NM_001079.4

p.Y87*

c.261C>G

1 paper

NM_001079.4

p.Y87N

c.259T>A

1 paper

NM_001079.4

p.R89R

c.267C>T

2 papers

NM_001079.4

p.F86I

c.256T>A

2 papers

NM_001079.4

p.D90A

c.269A>C

1 paper

NM_001079.4

p.D90G

c.269A>G

1 paper

NM_001079.4

p.E85G

c.254A>G

1 paper

NM_001079.4

p.C84C

c.252C>T

1 paper

NM_001079.4

p.C84G

c.250T>G

1 paper

NM_001079.4

p.D92G

c.275A>G

1 paper

NM_001079.4

p.G93A

c.278G>C