Varaico: Literature-Extracted Genetic Variants

ZC3HAV1

172 papers

RefSeq Summary

This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein play...

Pfam Domains

HTH_53aa 5–66UCSCZap helix turn helix N-terminal domain

zf-CCCH_PARP12aa 71–117UCSCPARP12-like CCCH zinc finger tandem

zf-CCCH_8aa 143–170UCSCZinc-finger antiviral protein (ZAP) zinc finger domain 3

WWE_4aa 536–590UCSCWWE domain

WWEaa 607–682UCSCWWE domain

PARPaa 737–868UCSCPoly(ADP-ribose) polymerase catalytic domain

Gene Aliases

HGNC Name

zinc finger CCCH-type containing, antiviral 1

HGNC Alias Symbols

FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; ARTD13

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_020119.4

p.E553V

c.1658A>T

Surrounding Variants

1 paper

NM_020119.4

p.H565Q

c.1695C>G

1 paper

NM_020119.4

p.H565Q

c.1695C>A

1 paper

NM_020119.4

p.K519N

c.1557G>T

1 paper

NM_020119.4

p.K519N

c.1557G>C

1 paper

NM_020119.4

p.K519R

c.1556A>G

1 paper

NM_020119.4

p.K519E

c.1555A>G

1 paper

NM_020119.4

p.K519Q

c.1555A>C

1 paper

NM_020119.4

p.S502insFs

c.1504_1505insGC

2 papers

NM_020119.4

p.R577W

c.1729C>T

1 paper

NM_020119.4

p.R577Q

c.1730G>A

3 papers

NM_020119.4

p.Q620*

c.1858C>T

1 paper

NM_020119.4

p.D491N

c.1471G>A