Varaico: Literature-Extracted Genetic Variants

ZC3HAV1

172 papers

RefSeq Summary

This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein play...

Pfam Domains

HTH_53aa 5–66UCSCZap helix turn helix N-terminal domain

zf-CCCH_PARP12aa 71–117UCSCPARP12-like CCCH zinc finger tandem

zf-CCCH_8aa 143–170UCSCZinc-finger antiviral protein (ZAP) zinc finger domain 3

WWE_4aa 536–590UCSCWWE domain

WWEaa 607–682UCSCWWE domain

PARPaa 737–868UCSCPoly(ADP-ribose) polymerase catalytic domain

Gene Aliases

HGNC Name

zinc finger CCCH-type containing, antiviral 1

HGNC Alias Symbols

FLB6421; FLJ13288; MGC48898; ZC3HDC2; ZC3H2; PARP13; ARTD13

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_020119.4

p.T316P

c.946A>C

Surrounding Variants

1 paper

NM_020119.4

p.K314R

c.941A>G

1 paper

NM_020119.4

p.S313Y

c.938C>A

1 paper

NM_020119.4

p.T326K

c.977C>A

1 paper

NM_020119.4

p.K296R

c.887A>G

1 paper

NM_020119.4

p.Q336E

c.1006C>G

1 paper

NM_020119.4

p.L293L

c.879C>T

1 paper

NM_020119.4

p.P344insFs

c.1031_1032ins5

1 paper

NM_020119.4

p.G345insFs

c.1033_1034ins5

1 paper

NM_020119.4

p.Y348F

c.1043A>T

1 paper

NM_020119.4

p.H341_L349Fs

c.1023_1047delinsGTTFs

1 paper

NM_020119.4

p.N343_L349delFs

c.1027_1046del20

1 paper

NM_020119.4

p.A268V

c.803C>T