Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head-Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Free Assay.
Koukourakis MI et al.
Current Oncology (toronto, Ont.), 2023
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1.
Un Nisa M et al.
Journal of Cell Communication and Signaling, 2023
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
Yu Z et al.
The Journal of Biological Chemistry, 2022
A role for AKT1 in nonsense-mediated mRNA decay.
Palma M et al.
Nucleic Acids Research, 2021
Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium.
Kim YJ et al.
Molecules and Cells, 2021
Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.
Asselta R et al.
Thoracic Cancer, 2021
A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology.
Wie J et al.
Nature, 2021
RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
Li T et al.
Nature Communications, 2021
Genomics of lethal prostate cancer at diagnosis and castration resistance.
Mateo J et al.
The Journal of Clinical Investigation, 2020
Targeted mutation detection in breast cancer using MammaSeq™.
Smith NG et al.
Breast Cancer Research : Bcr, 2019
AKT2 is the predominant AKT isoform expressed in human skeletal muscle.
Matheny RW et al.
Physiological Reports, 2018
UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.
Hu L et al.
Oncogene, 2017
BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation.
Swaminathan G et al.
Autophagy, 2016
Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.
Kopetz S et al.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2015
Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.
Li Q et al.
The Journal of Biological Chemistry, 2015
PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.
Lee MS et al.
Nature Communications, 2015
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.
Peres J et al.
Oncotarget, 2015
Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Abdalla M et al.
The Journal of Biological Chemistry, 2013
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma.
Zeng L et al.
Cancer Research, 2013
Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.
Griewank KG et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013
AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development.
Zhang J et al.
Neural Development, 2013
The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way.
Mediwala SN et al.
The Prostate, 2013
Disruption of PH-kinase domain interactions leads to oncogenic activation of AKT in human cancers.
Parikh C et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012
ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.
Khalil A et al.
Cell Cycle (georgetown, Tex.), 2011
Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.
Rodríguez-Escudero I et al.
The Journal of Biological Chemistry, 2009
AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition.
Caporali S et al.
Molecular Pharmacology, 2008
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.
Gao H et al.
Molecular and Cellular Biochemistry, 2007
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.
Baltzis D et al.
The Journal of Biological Chemistry, 2007
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2.
Lee IH et al.
The Journal of Biological Chemistry, 2007
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Somanath PR et al.
The Journal of Biological Chemistry, 2007
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Rosner M et al.
Human Molecular Genetics, 2007
Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts.
Oh JH et al.
Journal of Cellular Physiology, 2006
The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling.
Gherzi R et al.
Plos Biology, 2006
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation.
Song K et al.
The Embo Journal, 2006
Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.
Rodríguez-Escudero I et al.
The Biochemical Journal, 2005
Akt1 contains a functional leucine-rich nuclear export sequence.
Saji M et al.
Biochemical and Biophysical Research Communications, 2005
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.
Connor KM et al.
The Journal of Biological Chemistry, 2005
Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription.
Schinner S et al.
The Journal of Biological Chemistry, 2005
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
Bernal-Mizrachi E et al.
The Journal of Clinical Investigation, 2004
Insulin-response element-binding protein 1: a novel Akt substrate involved in transcriptional action of insulin.
Villafuerte BC et al.
The Journal of Biological Chemistry, 2004
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Song K et al.
The Journal of Biological Chemistry, 2003
Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway.
Zhang J et al.
Oncogene, 2003
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.
Potente M et al.
The Journal of Biological Chemistry, 2003
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Chen HK et al.
Cell, 2003
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway.
Stoica GE et al.
Oncogene, 2003
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site.
Toker A et al.
The Journal of Biological Chemistry, 2000
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Bellacosa A et al.
Oncogene, 1998