Varaico: Literature-Extracted Genetic Variants

Gene:AURKA
Variant:p.D274N
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AURKA

NM_198437.3:p.D274N

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer.

Yao J et al.

Frontiers in Immunology, 2025

40519936 (PubMed )
Supplement: Table1.xlsx › SNV

Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry.

Tavernier N et al.

Nature Communications, 2021

Redox priming promotes Aurora A activation during mitosis.

Lim DC et al.

Science Signaling, 2020

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity.

Byrne DP et al.

Science Signaling, 2020

Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.

Byrum AK et al.

The Journal of Cell Biology, 2019

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG et al.

The Embo Journal, 2018

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.

Burgess SG et al.

Open Biology, 2016

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.

Bibby RA et al.

The Journal of Biological Chemistry, 2009

HEF1-dependent Aurora A activation induces disassembly of the primary cilium.

Pugacheva EN et al.

Cell, 2007

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