Varaico: Literature-Extracted Genetic Variants

Gene:CASP3
Variant:p.L33R
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CASP3

NM_004346.4:p.L33R

Associated Papers

IDH1 and ATRX mutations synergistically modulate cell proliferation and ferroptosis in glioblastoma cells.

Liu S et al.

American Journal of Cancer Research, 2025

Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers.

Mao C et al.

Molecular Cell, 2024

Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation.

Miki K et al.

Oncogenesis, 2022

36195584 (PubMed )
Supplement: 41389_2022_437_MOESM1_ESM.pdf

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2.

Enrico TP et al.

Elife, 2021

PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells.

Huang T et al.

Molecular Cell, 2021

Synthetic Cannabinoids Induce Autophagy and Mitochondrial Apoptotic Pathways in Human Glioblastoma Cells Independently of Deficiency in TP53 or PTEN Tumor Suppressors.

Ellert-Miklaszewska A et al.

Cancers, 2021

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

Durant ST et al.

Science Advances, 2018

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ et al.

Cancer Cell, 2017

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.

Milella M et al.

Scientific Reports, 2017

Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.

Miyamoto Y et al.

International Journal of Oncology, 2010

[Identification of the hemolytic transfusion reaction caused by lewis antibody using serological and molecular biological methods].

Hong XZ et al.

Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2008

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis.

Weinmann L et al.

Cell Death and Differentiation, 2008

Shc3 affects human high-grade astrocytomas survival.

Magrassi L et al.

Oncogene, 2005

CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.

Wischhusen J et al.

Oncogene, 2003

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release.

Röhn TA et al.

Oncogene, 2001

p53 enhances BAK and CD95 expression in human malignant glioma cells but does not enhance CD95L-induced apoptosis.

Pohl U et al.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."