Varaico: Literature-Extracted Genetic Variants

Gene:FLT3
Variant:p.L4F
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FLT3

NM_004119.3:p.L4F

Associated Papers

Sphingosine-1-phosphate receptor modulators resensitize FLT3-ITD acute myeloid leukemia cells with NRAS mutations to FLT3 inhibitors.

Chatterjee A et al.

Biorxiv : the Preprint Server for Biology, 2025

Inhibition of FLT3-induced signalling in refractory acute myeloid leukaemia.

Yang J et al.

Bioorganic Chemistry, 2025

Inflammatory Giant Cell Carcinoma of the Lung: Clinicopathologic, Immunohistochemical, and Next-generation Sequencing Study of 14 Cases.

Suster DI et al.

The American Journal of Surgical Pathology, 2024

Rare variant associations with plasma protein levels in the UK Biobank.

Dhindsa RS et al.

Nature, 2023

37794183 (PubMed )
Supplement: 41586_2023_6547_MOESM4_ESM.zip › 2022-09-14560C-s4 › 2022-09-14560C-Supp_table_12_-_CH_QV_models.xlsx › Sheet2

Clinicopathologic Characteristics and Outcomes for Patients With KRAS G12D-Mutant NSCLC.

Cooper AJ et al.

Jto Clinical and Research Reports, 2022

36118132 (PubMed )
Supplement: mmc2.docx

Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups.

Egan C et al.

Haematologica, 2020

Targeted Sequencing Analysis of Pulmonary Adenocarcinoma with Multiple Synchronous Ground-Glass/Lepidic Nodules.

Park E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma.

Windon AL et al.

Journal of Gastrointestinal Oncology, 2018

RET Aberrations in Diverse Cancers: Next-Generation Sequencing of 4,871 Patients.

Kato S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

27683183 (PubMed )
Supplement: 10780432ccr161679-sup-168576_1_supp_3636667_wcc1ns.docx

Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service.

Hamblin A et al.

Plos Medicine, 2017

28196074 (PubMed )
Supplement: pmed.1002230.s015.docx

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing.

Hiemenz MC et al.

Plos One, 2016

27043212 (PubMed )
Supplement: pone.0152851.s001.xlsx › KRAS

Concurrent oncogene mutation profile in Chinese patients with stage Ib lung adenocarcinoma.

Wen YS et al.

Medicine, 2014

Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers.

Spaans VM et al.

Plos One, 2014

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ et al.

Cancer Discovery, 2013

23614898 (PubMed )
Supplement: 21598290cd130070-sup-supplementary_figures_-_pdf_file_1385k.pdf

Next-generation sequencing reveals high concordance of recurrent somatic alterations between primary tumor and metastases from patients with non-small-cell lung cancer.

Vignot S et al.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2013

N-ras mutation detection by pyrosequencing in adult patients with acute myeloid leukemia at a single institution.

Jeong JH et al.

Annals of Laboratory Medicine, 2013

Clinical significance of genetic aberrations in secondary acute myeloid leukemia.

Milosevic JD et al.

American Journal of Hematology, 2012

Keratinocytic epidermal nevi are associated with mosaic RAS mutations.

Hafner C et al.

Journal of Medical Genetics, 2012

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."