Varaico: Literature-Extracted Genetic Variants

Gene:HDAC3
Variant:p.Y298F
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HDAC3

NM_003883.4:p.Y298F

Associated Papers

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization.

Ma C et al.

Molecular Cancer, 2025

De novo missense variants in HDAC3 leading to epigenetic machinery dysfunction are associated with a variable neurodevelopmental disorder.

Yoon JG et al.

American Journal of Human Genetics, 2024

Regulation of pDC fate determination by histone deacetylase 3.

Zhang Y et al.

Elife, 2023

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation.

Li J et al.

Cell Discovery, 2023

NKAP acts with HDAC3 to prevent R-loop associated genome instability.

Zhang X et al.

Cell Death and Differentiation, 2023

Dichotomous engagement of HDAC3 activity governs inflammatory responses.

Nguyen HCB et al.

Nature, 2020

Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response.

Choi HK et al.

Nature Communications, 2015

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death.

Choi HK et al.

Human Molecular Genetics, 2015

Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Sun Z et al.

Molecular Cell, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."