Varaico: Literature-Extracted Genetic Variants

Gene:HTR1B
Variant:p.F124C
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HTR1B

NM_000863.3:p.F124C

Associated Papers

G protein-coupled receptor (GPCR) pharmacogenomics.

Thompson MD et al.

Critical Reviews in Clinical Laboratory Sciences, 2024

Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss.

Lewis MA et al.

Plos Genetics, 2023

Polymorphisms in the human serotonin receptor 1B (HTR1B) gene are associated with schizophrenia: a case control study.

Xia X et al.

Bmc Psychiatry, 2018

No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders.

Boudin E et al.

Bone, 2013

Gender-stratified gene and gene-treatment interactions in smoking cessation.

Lee W et al.

The Pharmacogenomics Journal, 2012

21808284 (PubMed )
Supplement: NIHMS305090-supplement-3.pdf

Pharmacological characterization of tegaserod at the wild type and 124Cys variant of the human 5-HT1B receptor.

Haenisch B et al.

Pharmacogenetics and Genomics, 2011

Association of unipolar depression with gene polymorphisms in the serotonergic pathways in Han Chinese.

Shi M et al.

Acta Neuropsychiatrica, 2008

G protein-coupled receptor pharmacogenetics.

Thompson MD et al.

Methods in Molecular Biology (clifton, N.j.), 2008

The phe-124-Cys and A-161T variants of the human 5-HT1B receptor gene are not major determinants of the clinical response to sumatriptan.

Mehrotra S et al.

Headache, 2007

5-Hydroxytryptamine-induced contraction of human temporal arteries coexpressing 5-HT2A receptors and wild-type or variant (Phe124Cys) 5-HT1B receptors: increased contribution of 5-HT1B receptors to the total contractile amplitude in arteries from Phe124Cys heterozygous individuals.

Verheggen R et al.

Pharmacogenetics and Genomics, 2006

Analysis of SNP profiles in patients with major depressive disorder.

Kõks S et al.

The International Journal of Neuropsychopharmacology, 2006

Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD.

Smoller JW et al.

Biological Psychiatry, 2006

Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes.

Proudnikov D et al.

Pharmacogenetics and Genomics, 2006

[Alcohol dependence and polymorphisms of serotonin-related genes].

Gorwood P et al.

Medecine Sciences : M/s, 2004

Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression.

Duan J et al.

Molecular Psychiatry, 2003

Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.

Huang YY et al.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2003

DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene.

Sanders AR et al.

Pharmacogenomics, 2002

Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han.

Sun HF et al.

Biological Psychiatry, 2002

The 5HT1Dbeta receptor gene in bipolar disorder: a family-based association study.

Mundo E et al.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 2001

Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence.

Cigler T et al.

American Journal of Medical Genetics, 2001

Genetic diversity of the human serotonin receptor 1B (HTR1B) gene.

Sanders AR et al.

Genomics, 2001

Pharmacological properties of the naturally occurring Phe-124-Cys variant of the human 5-HT1B receptor: changes in ligand binding, G-protein coupling and second messenger formation.

Kiel S et al.

Pharmacogenetics, 2000

Pharmacogenetics of schizophrenia.

Cichon S et al.

American Journal of Medical Genetics, 2000

Report of the Fourth International Chromosome 6 Workshop 1999. 10-12 June 1999. Cambridge, UK. Abstracts.

Mungall AJ et al.

Cytogenetics and Cell Genetics, 2000

Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue.

Huang YY et al.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 1999

Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor.

Brüss M et al.

Pharmacogenetics, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."